Oligonucleotide platform
Oligonucleotide
WuXi TIDES oligonucleotide platform provides comprehensive CRDMO services from drug discovery to commercial manufacturing for both drug substance and drug product.
End to End CRDMO Platform for Drugs
WuXi TIDES oligonucleotide platform provides comprehensive CRDMO services from drug discovery to commercial manufacturing for both drug substance and drug product.
Our oligonucleotide discovery synthesis services support high throughput library synthesis and custom synthesis (nmol-mmol). We cover all types of oligonucleotides, their monomers, linkers, ligands and conjugates. Additionally, we provide dedicated analytical support for all required testing.
We can seamlessly scale up to any scale (mmol – mol) to meet various demands from preclinical, clinical to commercial stages with ample capacities and proven capabilities with commercial success. Beyond chemistry, we provide formulation development and manufacturing services with various dosage forms and filling formats. These services are coupled with comprehensive analytical support for both API and drug product under one quality system, as well as the integrated CMC dossier preparation services, enabling our customers to bring their oligonucleotide therapeutics to market faster.
Oligonucleotide CRDMO Chemistry Platform
from Discovery to Development and Commercial Manufacturing
Monomer / Ligand
Oligonucleotide (from nmol to mol)
- DNA | ASO | PMO
- miRNA | siRNA | sgRNA
- Aptamer
- Degenerate Oligonucleotide Pools
Conjugate
- Oligonucleotide-Peptide
- Oligonucleotide-'Drug'
- Oligonucleotide-Lipid
- Oligonucleotide-GalNAc
- Dye-labelled Oligonucleotide
Services and Solutions
Discovery Synthesis
Development & Manufacturing
Why WuXi TIDES
What this platform adds
Scalability
From discovery to commercialisation entirely within WuXi TIDES, with readily available large R&D and manufacturing capacity.
Conjugation Chemistry
Seamless collaboration across the oligonucleotide, peptide and small molecule teams — the conjugates nobody else wants to touch.
New Technology
Biocatalysis for gRNA synthesis, thin film evaporation, reactor-in-series with PAT, continuous flow chromatography, TFF.
Global Quality Standard
One quality system across every site, approved by the major regulatory agencies around the world.
Comprehensive Analytical
Method development and validation, IPC and release testing, characterisation and stability under one roof.
Integrated CMC
API and formulation development, manufacturing, analytical, dossier preparation and clinical supply as a single programme.
Meeting global quality standards
Inspection record
How can we help?
Our TIDES drug experts stand ready.
Tell us where your molecule is today — discovery, CMC, or commercial supply — and we will map the fastest credible route to patients.
Small molecule projects? WuXi STA