Oligonucleotide · Development · API
Monomer & Ligand
We provide amidite development and manufacturing services and have dedicated plants for amidite production. Our capacity is more than 10 metric tons/year.
Amidite Production
Our team has extensive experience with 1,000+ customized amidite molecules with most challenging structures, to support your oligonucleotide projects from discovery to development and commercial stage, including:
- Sugar backbone (LNA, cEt, UNA, GNA, TNA amidite, etc.)
- Phosphorus backbone (PACE, PS2, etc.)
- 2'/3'/5' modified amidite
- Base modified amidite (tRNA base, deaza base)
We provide amidite development and manufacturing services and have dedicated plants for amidite production. Our capacity is more than 10 metric tons/year.
Sample amidite molecules
RNAi-Amidite
(2′-F, OMe Moe, OTBS, etc.)
LNA Amidite
TNA Amidite
Vpm-POM
DNA C(Bz) Amidite
PACE Amidite
Thio-Amidite
PMO Monomer
GalNAc Production
Our teams have extensive experience in the production of various types of GalNAc molecules, including Mono-GalNAc, Tri-GalNAc, Tetra-GalNAc, GalNAc amidite, GalNAc PFP ester, GalNAc N 3, GalNAc-PEG conjugate, etc.
We provide GalNAc custom synthesis, process development and manufacturing supporting from discovery phase all the way to commercial launch with batch scales ranging from milligrams to over 50 kilograms.
With our oligonucleotide teams at the same site in Changzhou, China, we provide a streamlined GalNAc-oligonucleotide conjugate development and manufacturing service. With various GalNAc building blocks and CPG/PS conjugate resins in stock, we can further accelerate your GalNAc-oligonucleotide projects.
Overcome GalNAc synthesis challenges
There are many synthetic challenges for GalNAc because most of the intermediates are oily or foamy solids. The synthesis involves many columns and prep-HPLC purification steps, resulting scale-up difficulties and low yields. Analytical method for GalNAc synthesis is also challenging due to low UV response, complex impurity profile and poor stability.
Original Process
Oil Intermediates
Modified Process
Solid Intermediates
Enabled by strong chemistry platform, WuXi TIDES developed convergent routes through telescoping processes without column purification steps. The isolated intermediates were stable solids. We applied the precipitation process and/or spray drying process to reduce the needs for the columns and prep-HPLC steps. Our analytical teams identified many GalNAc-related impurities to support method development and release testing.
Why WuXi TIDES
What this platform adds
Scalability
From discovery to commercialisation entirely within WuXi TIDES, with readily available large R&D and manufacturing capacity.
Conjugation Chemistry
Seamless collaboration across the oligonucleotide, peptide and small molecule teams — the conjugates nobody else wants to touch.
New Technology
Biocatalysis for gRNA synthesis, thin film evaporation, reactor-in-series with PAT, continuous flow chromatography, TFF.
Global Quality Standard
One quality system across every site, approved by the major regulatory agencies around the world.
Comprehensive Analytical
Method development and validation, IPC and release testing, characterisation and stability under one roof.
Integrated CMC
API and formulation development, manufacturing, analytical, dossier preparation and clinical supply as a single programme.
Meeting global quality standards
Inspection record
How can we help?
Our TIDES drug experts stand ready.
Tell us where your molecule is today — discovery, CMC, or commercial supply — and we will map the fastest credible route to patients.
Small molecule projects? WuXi STA